General Cell Lines and Cell Cultures
Genscript Corporation CHO-K1/GNRHR/G15 Stable Cell
The gonadotropin-releasing hormone receptor (GNRHR) also known as the luteinizing hormone releasing hormone receptor (LHRHR) is a member of the seven-transmembrane G-protein coupled receptor (GPCR) family It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes breast ovary and prostate Upon activation the LHRHr stimulates tyrosine phosphatase and elicits the release of LH from the pituitary Evidence exists showing the presence of LHRH and its receptor in extrapituitary tissues as well as a role in progression of some cancers
Sigma Aldrich Fine Chemicals Biosciences Blood-Brain Barrier hCMEC/D3 Cell Line The hCMEC/D3 BBB cell line has been extensively characterized for brain endothelial phenotype and is a model of human blood-brain barrier (BBB) function. |
Blood-Brain Barrier hCMEC/D3 Cell Line The hCMEC/D3 BBB cell line has been extensively characterized for brain endothelial phenotype and is a model of human blood-brain barrier (BBB) function. |
VITRO BIOPHARMA HUM BREAST CANCER ASSOC FIBROB
Human Breast Cancer Associate Fibroblasts: 1,000,000 Cells Per Vial.Cryopreserved at a low passageStage: IIIA
Genscript Corporation CHO-K1/OX-40L Stable Cell Line
Recombinant CHO-K1 cells stably overexpress human OX-40L on the surface The surface expression of OX-40L is validated by FACS analysis
Genscript Corporation CHO-K1/CD32B 232Thr Stable Cel
Recombinant CHO-K1 cells stably overexpress human immunoglobulin gamma Fc region receptor II-b (Fc RIIb/CD32B 232Thr) on the surface The surface expression of CD32B 232Thr is validated by FACS analysis This stable cell line product is designed for measuring binding affinity and stability of Fc region of antibodies and Fc fusion proteins or antibody based biologics binding with CD32B 232Thr GenScript also offers CD32B 232Ile stable cell line (Cat No M00587) for Fc RIIb polymorphism study
Amsbio LLC Mutation Quantification Control Plasma with 250 ng spike in DNA
Mutation Quantification Control Plasma with 250 ng spike in DNA
Sigma Aldrich Fine Chemicals Biosciences Human Dermal fibroblasts
Dermal fibroblasts are responsible for producing the extracellular matrix forming the connective tissue of the skin and play a crucial role during wound healing. HDf provide an excellent model system to study many aspects of cell physiology and have been utilized in dozens of research publications particularly those related to skin biology and reprogramming/induced pluripotency studies. HDf were used to create along with human synovyocytes induced pluripotent stem cells (iPSC) by using the now classic Yamanaka cocktail of Oct3/4 Sox2 Klf4 and c-Myc the discovery for which Dr. Shinya Yamanaka was awarded the Nobel Prize in 2012 (Takanashi 2007 2009) and to characterize iPSC general properties miRNA expression profiles and differentiation potential (Hayashi 2010 Ohta 2011 Koyanagi-Aoi 2013 Noguchi 20130 Razak 2013 Sakurai 2013 Tanaka 2013 Yanagida 2013)
STEMCELL Technologies Human Cord Blood Mononuclear Cells, Frozen, Size: 1.5 x 10^8 cells
Streamline your assays with ready-to-use, ethically sourced, primary mononuclear cells, including lymphocytes, monocytes, hematopoietic stem and progenitor cells, and mesenchymal stromal cells. With personalized service, custom products, flexible delivery times, and the option to reserve entire lots to prescreen cells for applications, we help you get the cells you need. Isolated from umbilical cord blood and cryopreserved in animal component-free CryoStorCS10 medium, cells are collected using Institutional Review Board (IRB) or other regulatory authority-approved consent forms and protocols. Additional documentation and high-resolution HLA typing (Class I and Class II alleles and CMV status) are available upon request. CPD is added as an anticoagulant. Contact techsupport@stemcell.com for donor specifications (BMI category, smoking status, ethnicity, etc.) Donors are screened for HIV-1, HIV-2, hepatitis B, and hepatitis C. Certain products are only available in select territories.
Genscript Corporation CHO-K1/G15/AMY2 Stable Cell L
Receptor activity-modifying proteins (RAMPs) are a class of protein which interact with and modulate the activities of several Class B G Protein-Coupled Receptors including the receptors for secretin calcitonin (CT) glucagon and vasoactive intestinal peptide (VIP) There are three distinct types of RAMPs designated RAMP1 RAMP2 and RAMP3 each encoded by a separate gene Currently the function of RAMPs is divided into 2 class activities Association of RAMPs with either the CT or CALCR proteins forms 6 different receptors from the calcitonin receptor family When associated with the Calcitonin receptor (CTR) or Calcitonin receptor-like (CALCRL) RAMPs can change the selectivity of the receptor for a specific hormone In the cases of the other receptors mentioned however there is no evidence that they can do this but instead function to regulate trafficking of receptors from the ER / golgi to the membrane GenScript s cloned human AMY2 (RAMP2 CALCR) expressing cell line is gen
Genscript Corporation CHO-K1/B7-H4 Stable Cell Line
B7-H4 is a transmembrane protein that binds an unknown receptor on activated T cells resulting in inhibition of T-cell effector function via cell cycle arrest decreased proliferation and reduced IL-2 production B7-H4 is up-regulated on the surface of cancer cells and immunosuppressive tumor-associated macrophages (TAMs) in a variety of human cancers
AdipoGen ODN 1668 (Type B) Endotoxin-free (sterile), 100 ug
MW: 6,383g/mol, Synonyms: CpG ODN TLR9 Agonist: B Type (species: rodent). Unmethylated CG dinucleotides within particular sequence contexts are responsible for the immunostimulatory activity of bacterial DNA. Synthetic oligonucleotides (ODN) that contain such CpG motifs (CpG ODNs) mimic microbial DNA. The innate immune system of vertebrates has the ability to recognize CpG motifs in microbial DNA via the Toll-like receptor (TLR) 9 if the CpG ODN were free of additional immune stimulatory contaminants often present in synthetic commercial CpG ODN preparations designed for molecular biology applications (i.e. PCR). Given that high quality CpG ODNs were used, a close link has been established between the expression of TLR9 on certain immune cell subsets and the modulation of the immune system by CpG DNA.
